4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
salbutamol free base
CAS: 18559-94-9;34391-04-3
Molecular Formula: C13H21NO3
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Names and Identifiers
| Name | salbutamol free base |
| Synonyms | sultanol ventolin proventil Albuterol Salbutamol LEVALBUTEROL Levalbuterol (L)-Albuterol LEVALBUTEROL HCL salbutamolfreebase salbutamol free base 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol 4-Hydroxy-3-hydroxymethyl-α-[(tert-butylamino)methyl]benzyl alcohol 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol Albuterol, α-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,αμ-diol |
| CAS | 18559-94-9 34391-04-3 |
| EINECS | 242-424-0 |
| InChI | InChI=1/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3 |
| InChIKey | NDAUXUAQIAJITI-UHFFFAOYSA-N |
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Physico-chemical Properties
| Molecular Formula | C13H21NO3 |
| Molar Mass | 239.32 |
| Density | 1.0700 (rough estimate) |
| Melting Point | 157-160℃ |
| Boling Point | 381.97°C (rough estimate) |
| Flash Point | 159.5°C |
| Water Solubility | 17.95g/L(25 ºC) |
| Solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). |
| Vapor Presure | 2.78E-08mmHg at 25°C |
| Appearance | neat |
| Color | White |
| Merck | 13,215 |
| BRN | 6405698 |
| pKa | pKa 9.07(H2Ot = 25.0±0.05I = 0.10) (Uncertain);10.37(H2Ot = 25.0±0.05I = 0.10) (Uncertain) |
| Storage Condition | 2-8°C |
| Stability | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4800 (estimate) |
| Physical and Chemical Properties | White or nearly white crystalline powder. Melting point 157-158 ° C, soluble in ethanol, soluble in water, slightly soluble in ether. Odorless and bitter. Its sulfate is a white to pale yellow crystalline powder. Soluble in water, soluble in ethanol, insoluble in chloroform or ether. Odorless and bitter. |
| Use | For the treatment of bronchial asthma, asthmatic bronchitis and other diseases |
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | ZE4400000 |
| HS Code | 2922504500 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Standard
Authoritative Data Verified Data
This product is l-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino) ethanol. Calculated as dried product, the content of C13H21N03 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in ethanol, slightly soluble in water, insoluble in ether.
melting point
The melting point of this product (General rule 0612) is 154~158°C, and it is decomposed at the same time during melting.
Last Update：2022-01-01 11:59:07
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add 2ml of water to dissolve, add 2 drops of iron gas test solution, shake, the solution is purple, add sodium bicarbonate test solution, the solution turns orange red.
- take this product, add 0.1 mol/L hydrochloric acid solution is prepared to contain about O. A solution of O8 MG has an absorption maximum at a wavelength of 0401 nm as determined by UV-Vis spectrophotometry (general).
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:59:07
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Exam
Authoritative Data Verified Data
optical rotation
take about 0.50g of this product, accurately weigh it, put it in a 25ml measuring flask, add methanol to dissolve and dilute to the scale, shake well, and determine it according to law (General rule 0621), the optical rotation should be from -0.10 ° to +0.10 °.
color of ethanol solution
take 0.40g of this product, add 10ml of anhydrous ethanol, and heat it in a warm water bath to dissolve it. If it is colored with the same volume of colorimetric solution (take 0.5ml of yellow stock solution and 10ml of anhydrous ethanol) (General Principles 0901, law I) for comparison, no deeper.
salbutamol
take 50.0 mg of this product, weigh it precisely, put it in a 25ml measuring flask, and add O.Olmol/L hydrochloric acid solution dissolved and diluted to the scale, shake, according to UV-visible spectrophotometry (General 0401), determination of absorbance at the wavelength of 310mn, not more than 0.10(0.2%).
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 2mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. An appropriate amount of terbutaline sulfate and salbutamol was taken, dissolved and diluted with mobile phase to prepare a solution containing about 0.2mg each in 1ml as a system applicable solution. According to high performance liquid chromatography (General rule 0512) test, using octanosilane bonded silica gel as filler; Using heptanesulfonate sodium solution [take heptanesulfonate 2.87g and potassium dihydrogen phosphate 2.5g, add water to dissolve and dilute to 1000ml, phosphoric acid solution (1-2) was used to adjust the pH value to 3.65]-acetonitrile (78:22) as mobile phase; The detection wavelength was 220nm. The system applicable solution 20u1 was injected into the liquid chromatograph, and the chromatogram was recorded. The resolution between the salbutamol peak and the Terbutaline peak should meet the requirements. 20ul of the test solution and the control solution respectively (sample injection within 12 hours after preparation) were injected into the human liquid chromatograph respectively, and the chromatogram was recorded to 25 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.3 times (0.3%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%). The peaks in the chromatogram of the test solution which were 0.05 times smaller than the main peak area of the control solution were ignored.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
boron
take 50mg of this product, add carbonate solution (take anhydrous sodium carbonate 1.7g and potassium carbonate 120g, add water to make 100ml), water bath to dry, after drying at °C, organic destruction was carried out by rapid ignition. After the destruction was complete, the mixture was allowed to cool. 0.5ml of water and 3ml of new 0.125% curcumin glacial acetic acid solution were added, add 3ml of sulfuric acid-glacial acetic acid solution (1:l), mix well, place for 30 minutes, transfer to lOOml measuring flask, dilute with ethanol to the scale, shake, filter, take the filtrate, according to UV-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 555nm; Take an appropriate amount of boric acid, add water to dissolve and quantitatively dilute to make a solution containing 5.72 tons per 1 ml, 1.5ml was accurately measured, and the same method was used from the above "adding 5ml of carbonate solution. The absorbance of the test solution should not be greater than that of the control solution (50 parts per million).
Last Update：2022-01-01 11:59:08
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 25ml dissolved, add crystal violet indicator liquid 1 drop, with high gas acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 23.93mg of C13H21N03.
Last Update：2022-01-01 11:59:09
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Category
Authoritative Data Verified Data
B2 adrenergic receptor agonists.
Last Update：2022-01-01 11:59:09
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:59:09
4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol - Salbutamol Inhalation Aerosol
Authoritative Data Verified Data
This product is salbutamol solution type or suspension type quantitative Inhalation Aerosol, stored in a quantitative valve system in a sealed container. This product before, during and after 10 each of the average per 10 per cent of albuterol (C13H21N03) should be labeled amount of 80.0% ~ 120.0%.
trait
The solution form is a colorless to yellowish clear liquid containing ethanol; The suspension form is a white or off-white suspension.
identification
- take 1 bottle of this product, drill a small hole through the aluminum cap with the injection needle (the suspension type needs to be frozen), remove the aluminum cap after air is discharged, and pour the contents into the test tube, add 2 drops of ferric chloride solution, shake, the solution is purple, and then add sodium bicarbonate solution to generate orange-red turbidity.
- take 1 bottle of this product, according to the identification (1) operation, take the content of methanol to make a solution containing about 1 mg of salbutamol per 1 ml, as the test solution (if the solution is turbid, then the filtrate was taken after filtration); An appropriate amount of salbutamol control was taken, dissolved in methanol and diluted to prepare a solution containing 1 mg per 1 ml as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel G thin layer plate, with ethyl acetate-isopropanol-water-concentrated ammonia solution (50:30:16:4) is a developing solvent, which is developed, dried, fumigated in diethylamine saturated steam for 5 minutes, taken out, and sprayed with diazonium-p-nitroaniline test solution to make color development. The position and color of the main spot displayed by the test solution should be the same as that of the reference solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- two items (2) and (3) above can be selected as one item.
examination
- Related substances take 1 bottle of this product, spray it several times under pressure (about 5mg equivalent to salbutamol) in a dry small beaker, add 10ml of mobile phase with precision, sonicate to dissolve salbutamol and filter it, the continuous filtrate was taken as the test solution; 1ml was accurately measured, placed in a 100ml measuring flask, diluted to the scale with the mobile phase, and shaken, as a control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%). The peaks in the chromatogram of the test solution which were 0.05 times smaller than the main peak area of the control solution were ignored.
- the dose of fine particles was measured according to the method for measuring aerodynamic characteristics of fine particles of an inhalation preparation (General rule 0951). The lower conical flask was filled with 30ml of ethanol-absorbing liquid, and the upper conical flask was filled with 7ml of ethanol-absorbing liquid. Take this product, fully shake, test for 5 times, press and spray for 20 Times (pay attention to 5 seconds interval and slowly shake), wash the specified parts with appropriate amount of ethanol, combine the wash solution with the absorption solution in the lower conical flask, put it in a 50ml measuring flask, dilute to the scale with ethanol, shake well, filter, and take the filtrate according to the chromatographic conditions under the content item, take 20 u1 for precise measurement, and inject it into human liquid chromatograph; Take appropriate amount of salbutamol reference substance, weigh it precisely, dissolve it with ethanol and quantitatively dilute it to make a solution containing 12ug per lml, and measure it with the same method. According to the external standard method based on the peak area, the amount of fine particles in the solution type aerosol should not be less than 20% of the label amount per hour, the amount of fine particles in the suspension type aerosol should not be less than 30% of the label amount per day.
- leakage rate: Take 12 bottles of the test article, remove the outer package, clean the surface with ethanol, and place it vertically (upright) at room temperature for 24 hours, and weigh it accurately (W1) respectively, then place it at room temperature for 72 hours (accurate to 30 minutes), then weigh the valve precisely (W2), place it at 2-8°C for cooling, and then quickly drill a small hole on the valve, place at room temperature, separate the bottle from the valve after complete vaporization of the propellant, wash it with ethanol, dry it at room temperature, and weigh it accurately (W3) respectively, the annual leakage rate per bottle was calculated according to the following equation. The average annual leakage rate should be less than 3.5%, and not more than 1 bottle 5%.
- In addition to the dose per spray and the uniformity of the delivered dose, the relevant provisions under aerosol (General rule 0113) shall be met.
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler, methanol-0.1% ammonium acetate solution (80:20) as mobile phase, the detection wavelength was 276mn. Appropriate amounts of terbutaline sulfate and salbutamol were taken, dissolved and diluted with mobile phase to prepare solutions containing 24ug each in 1 ml as the system applicable solution. The number of theoretical plates shall not be less than 3000 calculated by salbutamol peak, and the degree of separation between salbutamol peak and Terbutaline peak shall meet the requirements.
- determination of 1 bottle of this product, fully shake, test for 5 times, wash the nozzle and sleeve with mobile phase, fully dry, shake for 30 seconds, in a beaker filled with 30ml of human mobile phase absorbent solution, dip the sleeve under the level of human absorbent solution (at least 25mm), press and spray 10 times (every 5 seconds and slowly shake), take out, wash the inside and outside of the sleeve with absorption liquid, combine the washing liquid and absorption liquid, and transfer to 50ml measuring flask, dilute to the scale with mobile phase, shake well, take 20 u1 as the test solution, inject it into the liquid chromatograph, record the chromatogram; Take appropriate amount of salbutamol reference, weigh it accurately, the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing about 28UG (suspension type 20 tons) per 1 ml, which was determined by the same method. The peak area was calculated according to the external standard method, and the result was divided by 10, that is, the average content of the main drug in the first 10. According to the above method, respectively, and then determine the number of the mark (200 take 96~105 per bottle, or 240 take 116~125 per bottle), after that (200 to 191 for each bottle 200), or 240 to 231 for each bottle 240), the average content of the main drug was 1 μl per bottle.
category
B2 adrenergic receptor agonists.
specification
- Solution Type 200 per vial, containing salbutamol Mg per vial.
- suspension type 200 per vial, containing salbutamol O. 10 Mg per vial.
- suspension type 240 per vial, containing salbutamol O. 10 Mg per vial.
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 11:59:10
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Product Name: Salbutamol Visit Supplier Webpage Request for quotationCAS: 18559-94-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: salbutamol free base Request for quotation
CAS: 18559-94-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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CAS: 18559-94-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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